|
KMID : 0895420020120020079
|
|
Journal of Korean Society of Occupational and Enviromental Hygiene
2002 Volume.12 No. 2 p.79 ~ p.87
|
|
|
Comparison of urinary hippuric acid, toluene and o-cresol as biological exposure indicies for workers exposed to toluene
|
|
Kim Chi-Nyon
|
|
|
Abstract
|
|
|
This study was performed to compare the urinary hippuric acid, toluene and o-cresol as indices for biological exposure for workers exposed to toluene in air the statistical differences of various individual characteristics, the correlations between each biological exposure index and the concentration of individual exposure to toluene in air, and the statistical differences of the indices depending on sampling time points.
The results of the study are as follows;
1. Factors such as age, BMI, benzoic acid containing foods, alcohol, smoking, drug, coffee did not affect the excretion of urinary hippuric acid, urinary toluene and urinary 0-cresol.
2. For urinary hippuric acid, the correlation with the individual exposure concentration to tolune in air was statistically significant (r=0.632, p＜0.01) and the correlations for urinary toluence and o-cresol were r=0.035 and=0.114, respectively, thus the correlations were not statistically significant and low. Besides in cases lower than 10ppm, the correlation with the individual exposure concentration to tolune in air was statistically significant (r=0.447, p＜/0.01) but the correlation between the concentration of individual exposure to air-toluene and two biological monitoring indicies (urinary toluence and o-cresol) was not statistically significant.
3. Diffrence of biological exposure indecise in the begining and end of shift to indivisual exposure to toluene in air were statistically significant the urinary hippuric acid, toluene, and o-cresol in end of shift were higher than begining of work. However, in cases lower than 1ppm, diffrence of the urinary toluene and o-cresol were statistically in the begining and end of shift, but urinary hippuric acid was not.
We concluded that, while the individual characteristics(e.g., age, body mass index, benzoic acid containing foods, alcohol, smoking, drug, coffee) did not affect the excretion of urinary hippuric acid, toluene and o-cresol. But the excretion change through the begining and end of shift have the statistical significance, so sampling time at the end of shift was vary important.
Although the excretion of urinary hippuric acid showed significant correlation with the exposed toluene in air, urinary toluene and o-cresol wene recommended to be used as a subsidiary index in very low concentration of toluene in air.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|